Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies-Reference-Cited by-同舟云学术

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Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

Published:2019-09-05 Issue:22 Volume:62 Page:10062-10097
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Selnick Harold G.¹^ORCID,Hess J. Fred¹,Tang Cuyue¹,Liu Kun¹,Schachter Joel B.¹,Ballard Jeanine E.¹,Marcus Jacob¹,Klein Daniel J.¹,Wang Xiaohai¹,Pearson Michelle¹,Savage Mary J.¹,Kaul Ramesh²,Li Tong-Shuang²,Vocadlo David J.²^ORCID,Zhou Yuanxi²,Zhu Yongbao²,Mu Changwei³,Wang Yaode³,Wei Zhongyong³,Bai Chang³,Duffy Joseph L.¹,McEachern Ernest J.²^ORCID

Affiliation:

1. Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

2. Alectos Therapeutics Inc., 8999 Nelson Way, Burnaby, British Columbia V5A 4B5, Canada

3. Pharmaron Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China

Funder

Merck

Alectos Therapeutics Inc.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01090

Reference45 articles.

1. Neurodegenerative Tauopathies

2. Tau pathology and neurodegeneration

3. Tau and neurodegenerative disease: the story so far

5. Prion-like Spreading in Tauopathies

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