Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure–Activity Relationship and Preclinical Characterization-Reference-Cited by-同舟云学术

Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure–Activity Relationship and Preclinical Characterization

Published:2019-11-22 Issue:3 Volume:63 Page:944-960
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sinha Neelima¹,Karche Navnath P.¹^ORCID,Verma Mahip Kalyan¹,Walunj Sameer S.¹,Nigade Prashant B.¹,Jana Gourhari¹,Kurhade Sanjay P.¹,Hajare Anil K.¹,Tilekar Ajay R.¹,Jadhav Ganesh R.¹,Thube Baban R.¹,Shaikh Javed S.¹,Balgude Sudhakar¹,Singh Lairikyengbam Bikramjit¹,Mahimane Vijaya¹,Adurkar Shridhar K.¹,Hatnapure Girish¹,Raje Firoj¹,Bhosale Yogesh¹,Bhanage Dnyaneshwar¹,Sachchidanand Sachchidanand¹,Dixit Ruchi¹,Gupta Rajesh¹,Bokare Anand M.¹,Dandekar Manoj¹,Bharne Ashish¹,Chatterjee Manavi¹,Desai Sagar¹,Koul Sarita¹,Modi Dipak¹,Mehta Maneesh¹,Patil Vinod¹,Singh Minakshi¹,Gundu Jayasagar¹,Goel Rajan N.¹,Shah Chirag¹,Sharma Sharad¹,Bakhle Dhananjay¹,Kamboj Rajender Kumar¹,Palle Venkata P.¹

Affiliation:

1. Novel Drug Discovery & Development, Lupin Ltd., Lupin Research Park, Survey No. 46 A/47 A, Village Nande, Taluka Mulshi, Pune 412115, India

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01569

Reference48 articles.

1. Developing treatments for impaired cognition in schizophrenia

2. Cognition in schizophrenia: core psychological and neural mechanisms

3. Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) and Its Clinical Translation