Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1

Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1–13)-NH2

Published:2020-09-09 Issue:19 Volume:63 Page:10782-10795
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pacifico Salvatore¹^ORCID,Ferrari Federica²,Albanese Valentina¹,Marzola Erika¹,Neto Joaquim Azevedo²,Ruzza Chiara²³,Calò Girolamo²,Preti Delia¹^ORCID,Guerrini Remo¹³

Affiliation:

1. Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy

2. Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy

3. LTTA Laboratory for Advanced Therapies, Technopole of Ferrara, Via Fossato di Mortara 70, 44121 Ferrara, Italy

Funder

Universit? degli Studi di Ferrara

Ministero dell?Istruzione, dell?Universit? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b02057

Reference70 articles.

1. The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

2. Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems

3. NOP-Targeted Peptide Ligands

4. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

5. The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor

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