Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity-Reference-Cited by-同舟云学术

Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity

Published:2019-12-10 Issue:1 Volume:63 Page:369-381
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hlaváč Matúš¹,Kováčiková Lucia²,Prnová Marta Šoltésová²,Šramel Peter¹,Addová Gabriela³,Májeková Magdaléna²,Hanquet Gilles⁴,Boháč Andrej¹⁵,Štefek Milan²^ORCID

Affiliation:

1. Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovičova 6, 842 15 Bratislava, Slovakia

2. Institute of Experimental Pharmacology and Toxicology, CEM, SAS, Dúbravská cesta 9, 841 04 Bratislava, Slovakia

3. Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovičova 6, 842 15 Bratislava, Slovakia

4. Université de Strasbourg, Université de Haute-Alsace, CNRS, UMR 7042-LIMA, ECPM, 25 rue Becquerel, 67087 Strasbourg, France

5. Biomagi, Inc., Mamateyova 26, 851 04 Bratislava, Slovakia

Funder

Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

European Cooperation in Science and Technology

Türkiye Bilimsel ve Teknolojik Arastirma Kurumu

Slovenská Akadémia Vied

Agentúra na Podporu Výskumu a Vývoja

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b01747

Reference48 articles.

1. Identification of Novel Aldose Reductase Inhibitors Based on Carboxymethylated Mercaptotriazinoindole Scaffold

2. A Novel Carboxymethylated Mercaptotriazinoindole Inhibitor of Aldose Reductase Interferes With the Polyol Pathway in Streptozotocin-Induced Diabetic Rats

3. Toyooka, N.; Kato, A.; Adachi, I. Fused Tricyclic Compound Having Aldose Reductase Inhibitory Activity. U.S. Patent 20,100,145,052 A1, 2010.

4. Exploring the interactional details between aldose reductase (AKR1B1) and 3-Mercapto-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid through molecular dynamics simulations

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