Bioactivatable Pseudotripeptidization of Cyclic Dipeptides To Increase the Affinity toward Oligopeptide Transporter 1 for Enhanced Oral Absorption: An Application to Cyclo(l-Hyp-l-Ser) (JBP485)-Reference-Cited by-同舟云学术

Bioactivatable Pseudotripeptidization of Cyclic Dipeptides To Increase the Affinity toward Oligopeptide Transporter 1 for Enhanced Oral Absorption: An Application to Cyclo(l-Hyp-l-Ser) (JBP485)

Published:2019-08-08 Issue:17 Volume:62 Page:7708-7721
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jiang Qikun,Zhang Jiangnan¹,Tong Peiyue,Gao Yan,Lv Yiqin,Wang Changyuan¹,Luo Meiling,Sun Mengchi,Wang Jian²^ORCID,Feng Yao²,Cao Linlin³,Wang Gang⁴,Wang Yang⁴,Kan Qiming,Zhang Tianhong,Wang Yongjun,Liu Kexin¹,Sun Jin^ORCID,He Zhonggui

Affiliation:

1. Department of Clinical Pharmacology, Dalian Medical University, Dalian 116044, China

2. Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, China

3. Department of Pharmaceutics, The Second Hospital of Dalian Medical University, Dalian 116023, China

4. Department of Pharmaceutics, Guang Xi University of Chinese Medicine, Guangxi 530001, China

Funder

Department of Education of Liaoning Province

National Natural Science Foundation of China

Key Projects of Technology Bureau in Shenyang

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00358

Reference43 articles.

1. Cyclic dipeptides: from bugs to brain

2. Antimicrobial activity of cyclic dipeptides produced by Lactobacillus plantarum LBP-K10 against multidrug-resistant bacteria, pathogenic fungi, and influenza A virus

3. Synergistic antidiabetic activities of zinc, cyclo (His-Pro), and arachidonic acid

4. Uptake, Transport and Regulation of JBP485 by PEPT1 in vitro and in vivo

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis and evaluation of carbamate-bridged amino acid prodrugs of cycloicaritin with improved antitumor activity, aqueous solubility and phase II metabolic stability;European Journal of Medicinal Chemistry;2024-10

2. Natural Amino Acid-Bearing Carbamate Prodrugs of Daidzein Increase Water Solubility and Improve Phase II Metabolic Stability for Enhanced Oral Bioavailability;Journal of Agricultural and Food Chemistry;2024-04-03

3. Molecular Insights to the Structure-Interaction Relationships of Human Proton-Coupled Oligopeptide Transporters (PepTs);Pharmaceutics;2023-10-23

4. Design, synthesis and activity evaluation of prodrug form JBP485 and Vitamin E for alleviation of NASH;Bioorganic & Medicinal Chemistry Letters;2022-01

5. Modulation of Naturally Occurring Linear Dipeptide Chirality to Reduce the Affinity for Oligopeptide Transporter 1 and Increase Intestinal Stability for an Enhanced Colon-Targeting Effect in the Treatment of Inflammatory Bowel Disease: An Application of trans-4-l-Hydroxyprolyl-l-serine;Journal of Medicinal Chemistry;2021-11-29