Modulation of Naturally Occurring Linear Dipeptide Chirality to Reduce the Affinity for Oligopeptide Transporter 1 and Increase Intestinal Stability for an Enhanced Colon-Targeting Effect in the Treatment of Inflammatory Bowel Disease: An Application of trans-4-l-Hydroxyprolyl-l-serine-Reference-Cited by-同舟云学术

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Modulation of Naturally Occurring Linear Dipeptide Chirality to Reduce the Affinity for Oligopeptide Transporter 1 and Increase Intestinal Stability for an Enhanced Colon-Targeting Effect in the Treatment of Inflammatory Bowel Disease: An Application of trans-4-l-Hydroxyprolyl-l-serine

Published:2021-11-29 Issue: Volume: Page:
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jiang Qikun¹,Xu Qiuchi¹,Wang Yingli²,Li Pengyan¹,Zhang Yunran³,Wang Yongjun¹,Sun Jin¹^ORCID,Zhang Tianhong¹,He Zhonggui¹^ORCID

Affiliation:

1. Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China

2. Department of Pharmacy, Linyi People’s Hospital, Shandong University, Linyi 276002, China

3. Changzhou Pharmaceutical Factory Company Ltd., Changzhou 213018, China

Funder

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Liaoning Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01276

Reference27 articles.

1. Intestinal mucosal barrier function in health and disease

2. Understanding and Preventing the Global Increase of Inflammatory Bowel Disease

3. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

4. Intestinal barriers protect against disease

5. A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

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