Synthesis of Novel 4,1-Benzoxazepine Derivatives as Squalene Synthase Inhibitors and Their Inhibition of Cholesterol Synthesis-Reference-Cited by-同舟云学术

Synthesis of Novel 4,1-Benzoxazepine Derivatives as Squalene Synthase Inhibitors and Their Inhibition of Cholesterol Synthesis

Published:2002-08-30 Issue:20 Volume:45 Page:4571-4580
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Miki Takashi¹,Kori Masakuni¹,Mabuchi Hiroshi¹,Tozawa Ryu-ichi¹,Nishimoto Tomoyuki¹,Sugiyama Yasuo¹,Teshima Koichiro¹,Yukimasa Hidefumi¹

Affiliation:

1. Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., 2-17-85, Juso-Honmachi, Yodogawa-ku, Osaka 532-8686, Japan, and Strategic Product Planning Department, Takeda Chemical Industries, Ltd., 4-1-1, Doshomachi, Chuo-ku, Osaka 540-8645, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm020234o

Reference26 articles.

1. The Squalestatins: Inhibitors of Squalene Synthase. Enzyme Inhibitory Activities and in Vivo Evaluation of C3-Modified Analogues

2. Enantioselective synthesis of α-hydroxyketones using the ditox asymmetric building block

Cited by 78 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Brønsted Acid Triggers [6/7 + 1] Cascade Cyclization by N-Alkyl Amine C(sp³)–N Cleavage: Mild Synthesis of Benzo[1,4]oxazepane and Dihydrobenzo[1,5]oxazocine;The Journal of Organic Chemistry;2024-09-01

2. Highly Enantioselective Hydrogenation of Unsymmetrical Benzophenones via Iridium–f-phamidol Catalysis;Organic Letters;2024-07-18

3. Annulation Reactions of Isoquinolinium Ylides with Sulfamate-Derived Cyclic Imines toward Polycyclic 1,3-Benzoxazepine Heterocycles;Synthesis;2024-06-20

4. Deep Eutectic Solvents as Catalysts in the Synthesis of Active Pharmaceutical Ingredients and Precursors;Catalysts;2024-02-02

5. Inhibitors of Farnesyl Diphosphate Synthase and Squalene Synthase: Potential Source for Anti-Trypanosomatidae Drug Discovery;Drugs and Drug Candidates;2023-08-04