Efficient Synthesis of Novel NK1 Receptor Antagonists: Selective 1,4-Addition of Grignard Reagents to 6-Chloronicotinic Acid Derivatives-Reference-Cited by-同舟云学术

Efficient Synthesis of Novel NK1 Receptor Antagonists: Selective 1,4-Addition of Grignard Reagents to 6-Chloronicotinic Acid Derivatives

Published:2006-02-09 Issue:5 Volume:71 Page:2000-2008
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Hoffmann-Emery Fabienne¹,Hilpert Hans¹,Scalone Michelangelo¹,Waldmeier Pius¹

Affiliation:

1. F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Safety & Technical Sciences, Synthesis & Process Research, Grenzacherstrasse 124, CH-4070 Basel, Switzerland, and F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Discovery Chemistry, Lead Generation, Grenzacherstrasse 124, CH-4070 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo0523666

Reference37 articles.

1. Tachykinins and Tachykinin Receptors: Structure and Activity Relationships

2. A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) Receptor

3. Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors

4. Neurokinin antagonists and their potential role in treating depression and other stress disorders

5. Potential therapeutic targets for neurokinin-1 receptor antagonists

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