Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo-Reference-Cited by-同舟云学术

Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo

Published:2015-04-16 Issue:9 Volume:58 Page:3806-3816
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Burch Jason D.¹,Barrett Kathy¹,Chen Yuan¹,DeVoss Jason¹,Eigenbrot Charles¹,Goldsmith Richard¹,Ismaili M. Hicham A.¹,Lau Kevin¹,Lin Zhonghua¹,Ortwine Daniel F.¹,Zarrin Ali A.¹,McEwan Paul A.²,Barker John J.²,Ellebrandt Claire³,Kordt Daniel³,Stein Daniel B.³,Wang Xiaolu³,Chen Yong⁴,Hu Baihua⁴,Xu Xiaofeng⁴,Yuen Po-Wai⁴,Zhang Yamin⁴,Pei Zhonghua¹

Affiliation:

1. Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Evotec (U.K.) Ltd., 114 Milton Park, Abingdon, Oxfordshire OX14 4RZ, United Kingdom

3. Evotec AG, Manfred Eigen Campus, Essener Bogen 7, D-22419 Hamburg, Germany

4. Pharmaron Beijing Ltd. Co., No. 6 TaiHe Road BDA, 100176 Beijing, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501998m

Reference34 articles.