Discovery of potent and selective HPK1 inhibitors based on the 2,4-disubstituted pyrimidine scaffold with immune modulatory properties for ameliorating T cell exhaustion-Reference-Cited by-同舟云学术

Discovery of potent and selective HPK1 inhibitors based on the 2,4-disubstituted pyrimidine scaffold with immune modulatory properties for ameliorating T cell exhaustion

Published:2023-10 Issue: Volume:139 Page:106728
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Zeng Shenxin,Zeng Ming^ORCID,Yuan Shuai,He Liuxun,Jin Yuyuan,Huang Jiandong,Zhang Manxuan,yang Menghan,Pan Youlu,Wang Zunyuan,chen Yinqiao^ORCID,Xu Xiangwei^ORCID,Huang Wenhai

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference21 articles.

1. Defining 'T cell exhaustion';Blank;Nat. Rev. Immunol.,2019

2. Immune checkpoint therapy-current perspectives and future directions;Sharma;Cell,2023

3. Hematopoietic progenitor kinase 1 is a negative regulator of dendritic cell activation;Alzabin;J. Immunol.,2009

4. MAP4K Family Kinases in Immunity and Inflammation;Chuang;Adv. Immunol.,2016

5. MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade;Ebert;Immunity,2016

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody;European Journal of Medicinal Chemistry;2024-03

2. Discovery of highly efficient CRBN-recruiting HPK1-PROTAC as a potential chemical tool for investigation of scaffolding roles in TCR signaling;Bioorganic Chemistry;2024-02

3. Recent Advances in Pyrimidine-Based Drugs;Pharmaceuticals;2024-01-11