Characterization of Novel Glutathione Adducts of a Non-Nucleoside Reverse Transcriptase Inhibitor, (S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydro-2(1H)-quinazolinone (DPC 961), in Rats. Possible Formation of an Oxirene Metabolic Intermediate from a Disubstituted Alkyne-Reference-Cited by-同舟云学术

Characterization of Novel Glutathione Adducts of a Non-Nucleoside Reverse Transcriptase Inhibitor, (S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydro-2(1H)-quinazolinone (DPC 961), in Rats. Possible Formation of an Oxirene Metabolic Intermediate from a Disubstituted Alkyne

Published:2000-08-01 Issue:8 Volume:13 Page:775-784
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Mutlib Abdul¹,Chen Hao¹,Shockcor John¹,Espina Robert¹,Chen Sy¹,Cao Kevin¹,Du Alicia¹,Nemeth Greg¹,Prakash Shimoga¹,Gan Liang-Shang¹

Affiliation:

1. Drug Metabolism and Pharmacokinetics Section and Department of Chemical and Physical Sciences, DuPont Pharmaceuticals Company, Stine-Haskell Research Center, P.O. Box 30, 1094 Elkton Road, Newark, Delaware 19714

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx000029g

Reference29 articles.

1. HIV-1 RNA, CD4 cell count and the risk of progression to AIDS and death during treatment with HIV-1 reverse transcriptase inhibitors

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