Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain-Reference-Cited by-同舟云学术

Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

Published:2003-08-12 Issue:19 Volume:46 Page:3953-3956
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sawyer J. Scott¹,Anderson Bryan D.¹,Beight Douglas W.¹,Campbell Robert M.¹,Jones Michael L.¹,Herron David K.¹,Lampe John W.¹,McCowan Jefferson R.¹,McMillen William T.¹,Mort Nicholas¹,Parsons Stephen¹,Smith Edward C. R.¹,Vieth Michal¹,Weir Leonard C.¹,Yan Lei¹,Zhang Faming¹,Yingling Jonathan M.¹

Affiliation:

1. Discovery Chemistry Research and Technology, Cancer Research, and Lead Optimization Biology, The Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, and Lead Generation Chemistry, The Lilly Research Laboratories, A Division of Eli Lilly and Company, 20 T. W. Alexander Drive, Research Triangle Park, North Carolina 27709

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0205705

Reference21 articles.

1. The TGFβ Receptor Activation Process

2. Smad regulation in TGF-β signal transduction

3. Transforming growth factor β signaling mediators and modulators

4. Beyond mitomycin: TGF-β and wound healing

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