Drug Repositioning Using Computer-aided Drug Design (CADD)

Author:

Rawat Sona1,Subramaniam Kanmani2,Subramanian Selva Kumar3,Subbarayan Saravanan4,Dhanabalan Subramanian5,Chidambaram Sashik Kumar Madurai6,Stalin Balasubramaniam7,Roy Arpita8,Nagaprasad Nagaraj9,Aruna Mahalingam10,Tesfaye Jule Leta111213,Badassa Bayissa14,Krishnaraj Ramaswamy121314

Affiliation:

1. School of Life Sciences, Jaipur National University, Jaipur-302017, India

2. Department of Civil Engineering, KPR Institute of Engineering and Technology, Coimbatore-641407, Tamil Nadu, India

3. Department of Sciences, Amrita School of Engineering, Coimbatore - 641112, Tamil Nadu, India

4. Department of Civil Engineering, National Institute of Technology, Trichy-620015, Tamil Nadu, India

5. Department of Mechanical Engineering, M. Kumarasamy College of Engineering, Karur - 639113, Tamil Nadu, India

6. Centre for Water Resources, Department of Civil Engineering, Anna University, Chennai – 600 025, Tamil Nadu, India

7. Department of Mechanical Engineering, Anna University, Regional Campus Madurai, Madurai – 625 019, Tamil Nadu, India

8. Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida 201310, India

9. Department of Mechanical Engineering, ULTRA College of Engineering and Technology, Madurai - 625104, Tamilnadu, India

10. College of Engineering and Computing, Al Ghurair University, Academic City, Dubai, UAE

11. Dambi Dollo University, College of Natural and Computational Science, Department of Physics, Ethiopia

12. Centre for Excellence-Indigenous Knowledge, Innovative Technology Transfer and Entrepreneurship, Dambi Dollo University, Dambi Dollo, Ethiopia

13. Ministry of innovation and technology, Ethiopia

14. Department of Mechanical Engineering, Dambi Dollo University, Dambi Dollo, Ethiopia

Abstract

Abstract: Drug repositioning is a method of using authorized drugs for other unusually complex diseases. Compared to new drug development, this method is fast, low in cost, and effective. Through the use of outstanding bioinformatics tools, such as computer-aided drug design (CADD), computer strategies play a vital role in the re-transformation of drugs. The use of CADD's special strategy for target-based drug reuse is the most promising method, and its realization rate is high. In this review article, we have particularly focused on understanding the various technologies of CADD and the use of computer-aided drug design for target-based drug reuse, taking COVID-19 and cancer as examples. Finally, it is concluded that CADD technology is accelerating the development of repurposed drugs due to its many advantages, and there are many facts to prove that the new ligand-targeting strategy is a beneficial method and that it will gain momentum with the development of technology.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmaceutical Science,Biotechnology

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