Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity

Published:2001-01-31 Issue:5 Volume:44 Page:737-748
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gregson Stephen J.¹,Howard Philip W.¹,Hartley John A.¹,Brooks Natalie A.¹,Adams Lesley J.¹,Jenkins Terence C.¹,Kelland Lloyd R.¹,Thurston David E.¹

Affiliation:

1. CRC Gene Targeted Drug Design Research Group, Cancer Research Laboratories, University of Nottingham, University Park, Nottingham NG7 2RD, U.K., CRC Drug-DNA Interactions Research Group, Department of Oncology, University College London Medical School, London W1P 8BT, U.K., Yorkshire Cancer Research Laboratory of Drug Design, Cancer Research Group, University of Bradford, Bradford, West Yorkshire BD7 1DP, U.K., and CRC Centre for Cancer Therapeutics, Institute for Cancer Research, Clifton Avenue, Sutton,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm001064n

Reference37 articles.

1. Thurston, D. E. Advances in the Study of Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumour Antibiotics.Molecular Aspects of AnticancerDrug−DNA Interactions; The Macmillan Press Ltd. London, U.K., 1993; pp 54−88.

2. Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines

3. Solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines

4. Effect of A-Ring Modifications on the DNA-Binding Behavior and Cytotoxicity of Pyrrolo[2,1-c][1,4]benzodiazepines

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