Effect of A-Ring Modifications on the DNA-Binding Behavior and Cytotoxicity of Pyrrolo[2,1-c][1,4]benzodiazepines-Reference-Cited by-同舟云学术

Effect of A-Ring Modifications on the DNA-Binding Behavior and Cytotoxicity of Pyrrolo[2,1-c][1,4]benzodiazepines

Published:1999-05-18 Issue:11 Volume:42 Page:1951-1964
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thurston David E.¹,Bose D. Subhas¹,Howard Philip W.¹,Jenkins Terence C.¹,Leoni Alberto¹,Baraldi Pier G.¹,Guiotto Andrea¹,Cacciari Barbara¹,Kelland Lloyd R.¹,Foloppe Marie-Paule¹,Rault Sylvain¹

Affiliation:

1. CRC Gene Targeted Drug Design Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, St. Michael's Building, White Swan Road, Portsmouth, Hants P01 2DT, U.K., School of Chemical and Life Sciences, University of Greenwich, Wellington Street, Woolwich, London SE18 6PF, U.K., University of Ferrara, Via Fossato di Mortara 17/19, I-44100 Ferrara, Italy, CRC Centre for Cancer Therapeutics, Institute for Cancer Research, The Royal Cancer Hospital, Block E, Clifton Avenue, Sutton,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm981117p

Reference35 articles.

1. Recognition of 16 Base Pairs in the Minor Groove of DNA by a Pyrrole−Imidazole Polyamide Dimer

2. Neidle, S.; Puvvada, M. S.; Thurston, D. E. The Relevance of Drug−DNA Sequence-Specificity to Antitumour Activity.Eur.J.Cancer1994,30A, 567−568. Neidle, S.; Thurston, D. E. DNA Sequences as Targets for New Anticancer Agents. InNewTargetsforCancerChemotherapy; Kerr, D. J., Workman, P., Eds.; CRC Press Ltd. Boca Raton, FL, 1994; pp 159−175.

3. DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs

4. Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds

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