Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage-Reference-Cited by-同舟云学术

Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage

Published:2022 Issue:12 Volume:13 Page:1621-1633
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Joseph Asha Mary¹^ORCID,Nahar Kazi²,Daw Saheli¹,Hasan Md. Mahbub²^ORCID,Lo Rebecca³,Le Tung B. K.³,Rahman Khondaker Miraz²^ORCID,Badrinarayanan Anjana¹^ORCID

Affiliation:

1. National Centre for Biological Sciences (Tata Institute of Fundamental Research), Bangalore, India

2. School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK

3. John Innes Centre, Department of Molecular Microbiology, Colney Lane, Norwich, NR4 7UH, UK

Abstract

Our understanding about the mode of action of pyrrolobenzodiazepine (PBD) monomers remains incomplete. This study reveals the DNA damaging potential of PBD monomers in bacteria, and identifies mechanisms involved in repair of these PBD-adducts.

Funder

Science and Engineering Research Board

Department of Biotechnology, Ministry of Science and Technology, India

National Centre for Biological Sciences

Biotechnology and Biological Sciences Research Council

Commonwealth Scholarship Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/MD/D2MD00194B