Route Development and Multikilogram GMP Delivery of a Somatostatin Receptor Antagonist-Reference-Cited by-同舟云学术

Route Development and Multikilogram GMP Delivery of a Somatostatin Receptor Antagonist

Published:2012-08-01 Issue:8 Volume:16 Page:1329-1337
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Ruck Rebecca T.¹,Huffman Mark A.¹,Stewart Gavin W.²,Cleator Ed²,Kandur Wynne V.¹,Kim Mary M.¹,Zhao Dalian¹

Affiliation:

1. Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Department of Process Chemistry, Merck Sharp and Dohme Research Laboratories, Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op300128c

Reference18 articles.

1. Dobbelaar, P. H.; Du, W.; Guo, L.; Hagmann, W. K.; He, S.; Jian, T.; Liu, J.; Nargund, R. P.; Pasternak, A.; Shah, S. K.; Truong, Q. T.; Ye, Z.; Dellureficio, J.; Bakshi, R.WO/2009/011836 A1, 2009.

2. The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

3. Nitrosation of methyl 2-acylamino-3-dimethylaminopropenoates. A simple conversion ofn-acylglycines into 5-substituted 1,2,4-Oxadiazole-3-carboxylates

4. Synthesis of 1,2,4-Oxadiazole-, 1,3,4-Oxadiazole-, and 1,2,4-Triazole-Derived Dipeptidomimetics

5. Reactions of hydroxylamines with ethyl cyanoformate. preparation of aminonitrones and their synthetic applications.

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