The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes-Reference-Cited by-同舟云学术

The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

Published:2012-05-10 Issue:6 Volume:3 Page:484-489
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

He Shuwen¹,Ye Zhixiong¹,Truong Quang¹,Shah Shrenik¹,Du Wu¹,Guo Liangqin¹,Dobbelaar Peter H.¹,Lai Zhong¹,Liu Jian¹,Jian Tianying¹,Qi Hongbo¹,Bakshi Raman K.¹,Hong Qingmei¹,Dellureficio James¹,Pasternak Alexander¹,Feng Zhe¹,deJesus Reynalda¹,Yang Lihu¹,Reibarkh Mikhail¹,Bradley Scott A.¹,Holmes Mark A.¹,Ball Richard G.¹,Ruck Rebecca T.¹,Huffman Mark A.¹,Wong Frederick¹,Samuel Koppara¹,Reddy Vijay B.¹,Mitelman Stan¹,Tong Sharon X.¹,Chicchi Gary G.¹,Tsao Kwei-Lan¹,Trusca Dorina¹,Wu Margaret¹,Shao Qing¹,Trujillo Maria E.¹,Eiermann George J.¹,Li Cai¹,Zhang Bei B.¹,Howard Andrew D.¹,Zhou Yun-Ping¹,Nargund Ravi P.¹,Hagmann William K.¹

Affiliation:

1. Departments of †Medicinal Chemistry, ‡Process Research, §Drug Metabolism and Pharmacokinetics, and ∥Diabetes Research, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml300063m

Reference26 articles.

1. Phasic Insulin Release and Metabolic Regulation in Type 2 Diabetes

2. Global estimates of the prevalence of diabetes for 2010 and 2030

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5. A health economic analysis of screening and optimal treatment of nephropathy in patients with type 2 diabetes and hypertension in the USA

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