Identification of Guaifenesin–Andrographolide as a Novel Combinatorial Drug Therapy for Epilepsy Using Network Virtual Screening and Experimental Validation

Author:

Huang Yunyuan1,Xu Haiyan2,Wang Pei2,Gu Rurong2,Li Xiaokang1,Xu Yixiang1,Wang Jiqun1,Qiao Sicong1,Shi Donglei1,Gao Zhaobing2,Li Jian1345ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

2. CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

3. Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan, College of Pharmacy, Dali University, Dali 671000, China

4. Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, China

5. Key Laboratory of Tropical Biological Resources of Ministry of Education, College of Pharmacy, Hainan University, Haikou 570228, Hainan, China

Funder

National Natural Science Foundation of China

Innovation Program of Shanghai Municipal Education Commission

National Special Fund for State Key Laboratory of Bioreactor Engineering

Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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