Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine

Author:

Errico Silvia12,Ramshini Hassan13,Capitini Claudia45,Canale Claudio6,Spaziano Martina1,Barbut Denise7,Calamai Martino48ORCID,Zasloff Michael79,Oropesa-Nuñez Reinier10ORCID,Vendruscolo Michele2ORCID,Chiti Fabrizio1ORCID

Affiliation:

1. Department of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence, Florence 50134, Italy

2. Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom

3. Department of Biology, Payame Noor University, Tehran 19395-4697, Islamic Republic of Iran

4. European Laboratory for Non-linear Spectroscopy (LENS), Sesto Fiorentino 50019, Italy

5. Department of Physics and Astronomy, University of Florence, Sesto Fiorentino 50019, Italy

6. Department of Physics, University of Genoa, Genoa 16146, Italy

7. Enterin Inc., 2005 Market Street, Philadelphia, Pennsylvania 19103, United States

8. National Institute of Optics, National Research Council of Italy (CNR), Florence 50125, Italy

9. MedStar-Georgetown Transplant Institute, Georgetown University School of Medicine, Washington D.C. 20007, United States

10. Department of Materials Science and Engineering, Uppsala University, Uppsala SE-751 03, Sweden

Funder

Ministero dellâ??Istruzione, dellâ??Università e della Ricerca

Regione Toscana

Horizon 2020 Framework Programme

Università degli Studi di Firenze

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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