Single Molecule Fingerprinting Reveals Different Amplification Properties of α-Synuclein Oligomers and Preformed Fibrils in Seeding Assay-Reference-Cited by-同舟云学术

Single Molecule Fingerprinting Reveals Different Amplification Properties of α-Synuclein Oligomers and Preformed Fibrils in Seeding Assay

Published:2022-03-14 Issue:7 Volume:13 Page:883-896
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Lau Derrick¹^ORCID,Magnan Chloé¹,Hill Kathryn²,Cooper Antony²³,Gambin Yann¹,Sierecki Emma¹^ORCID

Affiliation:

1. EMBL Australia Node for Single Molecule Sciences and School of Medical Sciences, Faculty of Medicine, the University of New South Wales, Sydney, New South Wales 2052, Australia

2. The Australian Parkinson’s Mission, The Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia

3. St Vincent’s Clinical School, UNSW Sydney, Darlinghurst, New South Wales 2010, Australia

Funder

Australian Government

Michael J. Fox Foundation for Parkinson's Research

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.1c00553

Reference56 articles.

1. Parkinson's disease: clinical features and diagnosis

2. Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

3. In vivo demonstration that -synuclein oligomers are toxic

4. α-Synuclein, Especially the Parkinson's Disease-associated Mutants, Forms Pore-like Annular and Tubular Protofibrils

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