Putative Synthetic Cannabinoids MEPIRAPIM, 5F-BEPIRAPIM (NNL-2), and Their Analogues Are T-Type Calcium Channel (CaV3) Inhibitors

Author:

Kevin Richard C.12ORCID,Mirlohi Somayeh3,Manning Jamie J.4,Boyd Rochelle15,Cairns Elizabeth A.16,Ametovski Adam15,Lai Felcia2,Luo Jia Lin16,Jorgensen William5ORCID,Ellison Ross7,Gerona Roy R.7,Hibbs David E.2ORCID,McGregor Iain S.16,Glass Michelle4ORCID,Connor Mark3ORCID,Bladen Chris38,Zamponi Gerald W.8ORCID,Banister Samuel D.15ORCID

Affiliation:

1. The Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, NSW 2050, Australia

2. School of Pharmacy, The University of Sydney, NSW 2006, Australia

3. Faculty of Medicine, Health and Human Sciences, Macquarie University, NSW 2109, Australia

4. Department of Pharmacology and Toxicology, University of Otago, Dunedin 9016, New Zealand

5. School of Chemistry, The University of Sydney, NSW 2006, Australia

6. School of Psychology, The University of Sydney, NSW 2006, Australia

7. Clinical Toxicology and Environmental Biomonitoring Laboratory, University of California, San Francisco, California 94143, United States

8. Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada

Funder

University of Sydney

National Health and Medical Research Council

Health Research Council of New Zealand

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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