Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations-Reference-Cited by-同舟云学术

Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations

Published:2019-06-21 Issue:8 Volume:10 Page:3805-3814
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Bruno Agostino¹^ORCID,Barresi Elisabetta²,Simola Nicola³,Da Pozzo Eleonora²^ORCID,Costa Barbara²^ORCID,Novellino Ettore¹^ORCID,Da Settimo Federico²,Martini Claudia²^ORCID,Taliani Sabrina²^ORCID,Cosconati Sandro⁴^ORCID

Affiliation:

1. Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy

2. Department of Pharmacy, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy

3. Department of Biomedical Sciences, University of Cagliari, Monserrato University Campus, 09042 Monserrato, Italy

4. DiSTABiF, University of Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta, Italy

Funder

Universit? di Pisa

Ministero dell'Istruzione, dell'Universit? e della Ricerca

University of Campania Luigi Vanvitelli

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.9b00300

Reference56 articles.

1. The drug–target residence time model: a 10-year retrospective

2. Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

3. N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides. A New Class of Potent and Selective Ligands at the Peripheral Benzodiazepine Receptor

4. Anxiolytic-like Effects of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides by Modulation of Translocator Protein Promoting Neurosteroid Biosynthesis

5. Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides

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