Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Physalin F via Block of CaV2.3 (R-Type) and CaV2.2 (N-Type) Voltage-Gated Calcium Channels

Author:

Shan Zhiming12,Cai Song,Yu Jie3,Zhang Zhongjun1,Vallecillo Tissiana Gabriela menna,Serafini Maria Jin,Thomas Ann Mary,Pham Nancy Yen Ngan,Bellampalli Shreya Sai,Moutal Aubin,Zhou Yuan45,Xu Guo-Bo,Xu Ya-Ming,Luo Shizhen,Patek Marcel5,Streicher John M.ORCID,Gunatilaka A. A. Leslie,Khanna Rajesh6ORCID

Affiliation:

1. Department of Anesthesiology, Shenzhen People’s Hospital & Second Clinical Medical College of Jinan University, Shenzhen 518020, P.R. China

2. Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, P.R. China

3. College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310058, P.R. China

4. The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, P. R. China

5. BrightRock Path Consulting, LLC, Tucson 85721, Arizona, United States

6. The Center for Innovation in Brain Sciences, The University of Arizona Health Sciences, Tucson, Arizona 85724, United States

Funder

National Institute of Neurological Disorders and Stroke

Ministry of Science and Technology of the People's Republic of China

National Center for Complementary and Integrative Health

China Scholarship Council

National Institute on Drug Abuse

National Natural Science Foundation of China

Medical Scientific Research Foundation of Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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