C–H Functionalization-Enabled 11-Step Semisynthesis of (−)-Veragranine A and Characterization of Synthetic Analogs in Osteoarthritis-related Pain Treatment-Reference-Cited by-同舟云学术

C–H Functionalization-Enabled 11-Step Semisynthesis of (−)-Veragranine A and Characterization of Synthetic Analogs in Osteoarthritis-related Pain Treatment

Published:2024-06-06 Issue:24 Volume:146 Page:16698-16705
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Ma Donghui¹,Duran Paz²^ORCID,Al-Ahmad Reem¹^ORCID,Hestehave Sara²^ORCID,Joa Margarita²,Alsbiei Omar²,Rodríguez-Palma Erick J.²,Li Yanrong³^ORCID,Wang Shilin¹,Khanna Rajesh⁴^ORCID,Dai Mingji¹⁵^ORCID

Affiliation:

1. Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States

2. Department of Molecular Pathobiology, College of Dentistry, New York University, New York, New York 10010, United States

3. Department of Chemistry, Purdue University, West Lafayette, Indiana 47906, United States

4. Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida 32610, United States

5. Department of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, Georgia 30322, United States

Funder

National Institute of Neurological Disorders and Stroke

National Institute of General Medical Sciences

University of Florida

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.4c04025

Reference31 articles.

1. Prevalence of chronic pain among adults in the United States

2. Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels

3. Lack of Evidence for Benefit From Long-term Use of Opioid Analgesics for Patients With Neuropathy

4. Cellular and Molecular Mechanisms of Pain

5. Steroidal Alkaloids with a Potent Analgesic Effect Based on N-type Calcium Channel Inhibition

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