Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo

Author:

Mäki-Opas Ilari1ORCID,Hämäläinen Mari1,Moilanen Lauri J.1,Haavikko Raisa2,Ahonen Tiina J.2,Alakurtti Sami23,Moreira Vânia M.24ORCID,Muraki Katsuhiko5,Yli-Kauhaluoma Jari2ORCID,Moilanen Eeva1

Affiliation:

1. The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 33014 Tampere, Finland

2. Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, Finland

3. VTT Technical Research Centre of Finland Ltd., 02044 Espoo, Finland

4. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.

5. Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650, Japan

Funder

FP7 Food, Agriculture and Fisheries, Biotechnology

FP7 Health

Paulon Säätiö

Suomen Akatemia

Tampere University Hospital

Tor, Joe ja Pentti Borg -Säätiö

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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