Design, Synthesis, and Pharmacological Evaluation of Embelin–Aryl/alkyl Amine Hybrids as Orally Bioavailable Blood–Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer’s Disease: Discovery of SB-1448-Reference-Cited by-同舟云学术

Design, Synthesis, and Pharmacological Evaluation of Embelin–Aryl/alkyl Amine Hybrids as Orally Bioavailable Blood–Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer’s Disease: Discovery of SB-1448

Published:2023-02-22 Issue:6 Volume:14 Page:1193-1219
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Nuthakki Vijay K.¹²^ORCID,Choudhary Sushil³²,Reddy Chilakala N.¹²,Bhatt Shipra³²,Jamwal Ashiya³²,Jotshi Anshika³,Raghuvanshi Rinky¹²,Sharma Ankita¹²,Thakur Shikha⁴,Jadhav Hemant R.⁴,Bharate Sonali S.⁵^ORCID,Nandi Utpal³²^ORCID,Kumar Ajay³²,Bharate Sandip B.¹²^ORCID

Affiliation:

1. Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India

2. Academy of Scientific & Innovative Research (AcSIR), Ghaziabad 201002, India

3. Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India

4. Department of Pharmacy, Birla Institute of Technology and Sciences Pilani, Pilani Campus, Vidya Vihar, Pilani 333031, Rajasthan, India

5. Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India

Funder

Council of Scientific and Industrial Research

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.3c00030

Reference104 articles.

1. Dementia Fact Sheet, 2022. https://www.who.int/news-room/fact-sheets/detail/dementia.

2. Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019

3. Alzheimer's disease

4. Alzheimer disease

5. The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

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