Design, Synthesis, and Pharmacological Evaluation of Embelin–Aryl/alkyl Amine Hybrids as Orally Bioavailable Blood–Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer’s Disease: Discovery of SB-1448-Reference-Cited by-同舟云学术

Design, Synthesis, and Pharmacological Evaluation of Embelin–Aryl/alkyl Amine Hybrids as Orally Bioavailable Blood–Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer’s Disease: Discovery of SB-1448

Published:2023-02-22 Issue:6 Volume:14 Page:1193-1219
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Nuthakki Vijay K.¹²^ORCID,Choudhary Sushil³²,Reddy Chilakala N.¹²,Bhatt Shipra³²,Jamwal Ashiya³²,Jotshi Anshika³,Raghuvanshi Rinky¹²,Sharma Ankita¹²,Thakur Shikha⁴,Jadhav Hemant R.⁴,Bharate Sonali S.⁵^ORCID,Nandi Utpal³²^ORCID,Kumar Ajay³²,Bharate Sandip B.¹²^ORCID

Affiliation:

1. Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India

2. Academy of Scientific & Innovative Research (AcSIR), Ghaziabad 201002, India

3. Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India

4. Department of Pharmacy, Birla Institute of Technology and Sciences Pilani, Pilani Campus, Vidya Vihar, Pilani 333031, Rajasthan, India

5. Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India

Funder

Council of Scientific and Industrial Research

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.3c00030

Reference104 articles.

1. Dementia Fact Sheet, 2022. https://www.who.int/news-room/fact-sheets/detail/dementia.

2. Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019

3. Alzheimer's disease

4. Alzheimer disease

5. The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis, and pharmacological evaluation of indole-piperidine amides as Blood−brain barrier permeable dual cholinesterase and β-secretase inhibitors;European Journal of Medicinal Chemistry;2024-02

2. Synthesis of novel rapanone derivatives via organocatalytic reductive C-alkylation: biological evaluation of antioxidant properties, in vivo zebrafish embryo toxicity, and docking studies;RSC Medicinal Chemistry;2024

3. Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of breast cancer;Chemico-Biological Interactions;2023-09

4. Novel Lawsone–Quinoxaline Hybrids as New Dual Binding Site Acetylcholinesterase Inhibitors;ACS Omega;2023-08-29

5. Rottlerin renders a selective and highly potent CYP2C8 inhibition to impede EET formation for implication in cancer therapy;Chemico-Biological Interactions;2023-08