Synthesis and Preclinical Evaluation of 22-[18F]Fluorodocosahexaenoic Acid as a Positron Emission Tomography Probe for Monitoring Brain Docosahexaenoic Acid Uptake Kinetics

Author:

Duro Marlon Vincent V.1,Van Valkenburgh Juno1,Ingles Diana E.2,Tran Jenny2,Cai Zhiheng2,Ebright Brandon3ORCID,Wang Shaowei2,Kerman Bilal E.2ORCID,Galvan Jasmin2,Hwang Sung Hee4ORCID,Sta Maria Naomi S.5,Zanderigo Francesca67,Croteau Etienne8,Cunnane Stephen C.9,Rapoport Stanley I.10,Louie Stan G.3,Jacobs Russell E.5,Yassine Hussein N.2,Chen Kai1ORCID

Affiliation:

1. Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States

2. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States

3. Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, United States

4. Department of Entomology and Nematology and UC Davis Comprehensive Cancer Center, University of California, Davis, California 95616, United States

5. Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States

6. Department of Psychiatry, Columbia University, New York, New York 10032, United States

7. Molecular Imaging and Neuropathology Area, New York State Psychiatric Institute, New York, New York 10032, United States

8. Sherbrooke Center for Molecular Imaging, University of Sherbrooke, Sherbrooke, QC J1H 4C4, Canada

9. Research Center on Aging, Department of Medicine, University of Sherbrooke, Sherbrooke, QC J1H 4C4, Canada

10. National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, United States

Funder

Alzheimer's Drug Discovery Foundation

National Institute on Aging

Tiny Foundation

Vranos

Ms. Lynne Nauss

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

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