Discovery and Preclinical Validation of [11C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor-Reference-Cited by-同舟云学术

Discovery and Preclinical Validation of [11C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor

Published:2015-11-30 Issue:2 Volume:7 Page:177-184
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Schou Magnus¹,Varnäs Katarina²,Jureus Anders³,Ahlgren Charlotte³,Malmquist Jonas³,Häggkvist Jenny²,Tari Lenke²,Wesolowski Steven S.⁴,Throner Scott R.⁵,Brown Dean G.⁵,Nilsson Maria³,Johnström Peter¹,Finnema Sjoerd J.²,Nakao Ryuji²,Amini Nahid²,Takano Akihiro²,Farde Lars¹

Affiliation:

1. AstraZeneca Translational Science Centre at Karolinska Institutet, PET Centre of Excellence, Department of Clinical Neuroscience, S-17176 Stockholm, Sweden

2. Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, S-17176 Stockholm, Sweden

3. AstraZeneca, Research & Development, Innovative Medicines, S-151 85 Södertälje, Sweden

4. AstraZeneca, Research & Development, Innovative Medicines, Cambridge, Massachusetts 02451, United States

5. AstraZeneca, Research & Development, Innovative Medicines, Waltham, Massachusetts 02139, United States

Funder

AstraZeneca

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5b00268

Reference23 articles.

1. Histamine H3 Receptor: A Potential Drug Target for the Treatment of Central Nervous System Disorders

2. The medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor

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4. Rare Copy Number Variants in Tourette Syndrome Disrupt Genes in Histaminergic Pathways and Overlap with Autism

5. H3 Receptors and Pain Modulation: Peripheral, Spinal, and Brain Interactions

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