Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery
Author:
Affiliation:
1. Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States
Publisher
American Chemical Society (ACS)
Subject
Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00029
Reference16 articles.
1. Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes
2. Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties
3. Probabilistic Approach to Generating MPOs and Its Application as a Scoring Function for CNS Drugs
4. Quantifying the chemical beauty of drugs
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