A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage-Reference-Cited by-同舟云学术

A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage

Published:2017-02-16 Issue:6 Volume:8 Page:1262-1278
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Lensing Cody J.¹,Adank Danielle N.¹,Wilber Stacey L.¹,Freeman Katie T.¹,Schnell Sathya M.¹,Speth Robert C.²³,Zarth Adam T.¹⁴,Haskell-Luevano Carrie¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States

2. College of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida 33328-2018, United States

3. Department of Pharmacology and Physiology, Georgetown University, Washington, D.C. 20057, United States

4. Masonic Cancer Center, University of Minnesota, 2231 6th Street SE, 2-210 CCRB, Minneapolis, Minnesota 55455, United States

Funder

National Institute for Health NIDDK

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00399

Reference120 articles.

1. A Bivalent Ligand (KDN-21) Reveals Spinal δ and κ Opioid Receptors Are Organized as Heterodimers That Give Rise to δ1 and κ2 Phenotypes. Selective Targeting of δ−κ Heterodimers

2. Heterobivalent ligands target cell-surface receptor combinations in vivo

3. Opioid agonist and antagonist bivalent ligands as receptor probes

4. Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors

5. Binaltorphimine-related bivalent ligands and their .kappa. opioid receptor antagonist selectivity

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