Comparative in Vivo Investigation of Intrathecal and Intracerebroventricular Administration with Melanocortin Ligands MTII and AGRP into Mice
Author:
Affiliation:
1. Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States
2. Department of Psychology, California State University Bakersfield, Bakersfield, California 93311, United States
Funder
National Institute of Diabetes and Digestive and Kidney Diseases
Publisher
American Chemical Society (ACS)
Subject
Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.7b00330
Reference34 articles.
1. Implication of the melanocortin-3 receptor in the regulation of food intake
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3. Long-term orexigenic effects of AgRP-(83—132) involve mechanisms other than melanocortin receptor blockade
4. Central Administration of Ghrelin and Agouti-Related Protein (83–132) Increases Food Intake and Decreases Spontaneous Locomotor Activity in Rats
5. Theoretical and practical applications of the intracerebroventricular route for CSF sampling and drug administration in CNS drug discovery research: A mini review
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1. Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)];ACS Pharmacology & Translational Science;2024-04-02
2. Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design;Journal of Medicinal Chemistry;2024-02-12
3. The Parallel Structure–Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands;International Journal of Molecular Sciences;2023-06-14
4. Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2′)-Orn-NH2] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2′)-Arg-NH2];Journal of Medicinal Chemistry;2023-06-12
5. Investigating the role of the central melanocortin system in stress and stress-related disorders;Pharmacological Research;2022-11
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