Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X7 Receptor Antagonist-Reference-Cited by-同舟云学术

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Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X7 Receptor Antagonist

Published:2017-08-25 Issue:11 Volume:8 Page:2374-2380
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Wilkinson Shane M.,Barron Melissa L.,O’Brien-Brown James,Janssen Bieneke¹,Stokes Leanne²,Werry Eryn L.,Chishty Mansoor³,Skarratt Kristen K.,Ong Jennifer A.,Hibbs David E.,Vugts Danielle J.¹,Fuller Stephen,Windhorst Albert D.¹,Kassiou Michael^ORCID

Affiliation:

1. Department of Radiology & Nuclear Medicine, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands

2. School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, U.K.

3. Pharmidex, 14 Hanover St., Mayfair, London W1S 1YH, U.K.

Funder

National Health and Medical Research Council

Seventh Framework Programme

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.7b00272

Reference26 articles.

1. The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease

2. Selective P2X7 receptor antagonists for chronic inflammation and pain

3. Molecular Probes for P2X7 Receptor Studies

4. P2X7 receptor antagonists: a patent review (2010–2015)

5. Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X7 Receptor Antagonists/Interleukin-1β Inhibitors

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1. Unlocking therapeutic potential: the role of adamantane in drug discovery;Australian Journal of Chemistry;2024-08-02

2. Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders;Frontiers in Pharmacology;2024-07-30

3. An Investigation on Linker Modifications of Cyanoguanidine‐Based P2X7 Receptor Antagonists;ChemMedChem;2024-07-12

4. Synthesis and Properties of N,N′-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments. XX. N-[(3,5-Difluoroadamantan-1-yl)]-N′-R-ureas and Symmetrical Bis-ureas;Russian Journal of Organic Chemistry;2024-06

5. Synthesis and properties of 1-(3,5,7-trifluoroadamantan-1-yl)-3-R-ureas;Russian Chemical Bulletin;2024-06

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