Synthesis and Preclinical Evaluation of [<sup>11</sup>C]AZ11895530 for PET Imaging of the Serotonin 1A Receptor-Reference-Cited by-同舟云学术

Synthesis and Preclinical Evaluation of [¹¹C]AZ11895530 for PET Imaging of the Serotonin 1A Receptor

Published:2022-07-08 Issue:14 Volume:13 Page:2078-2083
ISSN:1948-7193
Container-title:ACS Chemical Neuroscience
language:en
Short-container-title:ACS Chem. Neurosci.

Author:

Dahl Kenneth¹²^ORCID,Johnström Peter³⁴,Forsberg-Morén Anton³,Gustafsson Björn³,Miranda-Azpiazu Patricia³,Khani Yaser³,Halldin Christer³,Farde Lars³,Elmore Charles S.⁵,Schou Magnus³⁴^ORCID

Affiliation:

1. Department of Radiopharmacy, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

2. Department of Oncology and Pathology, Kaolinska Institutet, SE-171 76 Stockholm, Sweden

3. Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Hospital, S-171 76 Stockholm, Sweden

4. PET Science Centre at Karolinska Institutet, Precision Medicine and Biosamples, AstraZeneca, S-171 76 Stockholm, Sweden

5. Isotope Chemistry, Early Chemical Development, Pharmaceutical Science, R&D, AstraZeneca, 431 50 Mölndal, Sweden

Funder

AstraZeneca

Publisher

American Chemical Society (ACS)

Subject

Cell Biology,Cognitive Neuroscience,Physiology,Biochemistry,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.2c00205

Reference22 articles.

1. A review of central 5-HT receptors and their function

2. [3H]WAYâ100635 for 5âHT1A receptor autoradiography in human brain: a comparison with [3H]8âOHâDPAT and demonstration of increased binding in the frontal cortex in schizophrenia

3. Brain Serotonin1A Receptor Binding in Major Depression Is Related to Psychic and Somatic Anxiety

4. Serotonin 1A receptors in the living brain of Alzheimer's disease patients

5. Role of serotonergic 1A receptor dysfunction in depression associated with Parkinson's disease

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