Allosteric Modulation of the Dopamine D2 Receptor by Pro-Leu-Gly-NH2 Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation-Reference-Cited by-同舟云学术

Allosteric Modulation of the Dopamine D2 Receptor by Pro-Leu-Gly-NH2 Peptidomimetics Constrained in Either a Polyproline II Helix or a Type II β-Turn Conformation

Published:2009-03-09 Issue:7 Volume:52 Page:2043-2051
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Raghavan Bhooma¹,Skoblenick Kevin J.¹,Bhagwanth Swapna¹,Argintaru Niran¹,Mishra Ram K.¹,Johnson Rodney L.¹

Affiliation:

1. Department of Medicinal Chemistry, University of Minnesota, 308 Harvard Street, SE, Minneapolis, Minnesota 55455, and Department of Psychiatry and Behavioral Neuroscience, McMaster University, 1200 Main Street W., Hamilton, Ontario L8N 3Z5, Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801575w

Reference15 articles.

1. Interaction of l-Prolyl-l-Leucyl Glycinamide with Dopamine D2Receptor: Evidence for Modulation of Agonist Affinity States in Bovine Striatal Membranes

2. Modulation of Agonist Binding to Human Dopamine Receptor Subtypes by l-Prolyl-l-leucyl-glycinamide and a Peptidomimetic Analog

3. Design and Synthesis of Photoaffinity-Labeling Ligands of the l-Prolyl-l-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor

4. Design, Synthesis, X-ray Analysis, and Dopamine Receptor-Modulating Activity of Mimics of the "C5" Hydrogen-Bonded Conformation in the Peptidomimetic 2-Oxo-3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-1-pyrrolidineacetamide

5. Neuroleptic Drug-Induced Dopamine Receptor Supersensitivity: Antagonism by L-Prolyl-L-Leucyl-Glycinamide

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