Bispyrimidines as Potent Histamine H4 Receptor Ligands: Delineation of Structure–Activity Relationships and Detailed H4 Receptor Binding Mode-Reference-Cited by-同舟云学术

Bispyrimidines as Potent Histamine H4 Receptor Ligands: Delineation of Structure–Activity Relationships and Detailed H4 Receptor Binding Mode

Published:2013-05-28 Issue:11 Volume:56 Page:4264-4276
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Engelhardt Harald¹²,Schultes Sabine¹²,de Graaf Chris²,Nijmeijer Saskia²,Vischer Henry F.²,Zuiderveld Obbe P.²,Dobler Julia¹,Stachurski Katharina¹,Mayer Moriz¹,Arnhof Heribert¹,Scharn Dirk¹,Haaksma Eric E. J.¹²,de Esch Iwan J. P.²,Leurs Rob²

Affiliation:

1. Boehringer Ingelheim RCV GmbH & Co KG, Department of Medicinal Chemistry, Dr. Boehringergasse 5-11, 1121 Vienna, Austria

2. Amsterdam Institute of Molecules, Medicines and Systems (AIMMS), Division of Medicinal Chemistry, Department of Pharmacochemistry, Faculty of Exact Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301886t

Reference47 articles.

1. Cloning and Pharmacological Characterization of a Fourth Histamine Receptor (H4) Expressed in Bone Marrow

2. Discovery of a Novel Member of the Histamine Receptor Family

3. Cloning, Expression, and Pharmacological Characterization of a Novel Human Histamine Receptor

4. The histamine H4 receptor: A novel modulator of inflammatory and immune disorders

5. Functional Expression of H4 Histamine Receptor in Human Natural Killer Cells, Monocytes, and Dendritic Cells

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