A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold-Reference-Cited by-同舟云学术

A Divergent SAR Study Allows Optimization of a Potent 5-HT2c Inhibitor to a Promising Antimalarial Scaffold

Published:2012-02-16 Issue:5 Volume:3 Page:373-377
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Calderón Félix¹,Vidal-Mas Jaume¹,Burrows Jeremy²,de la Rosa Juan Carlos¹,Jiménez-Díaz María Belén¹,Mulet Teresa¹,Prats Sara¹,Solana Jorge¹,Witty Michael²,Gamo Francisco Javier¹,Fernández Esther¹

Affiliation:

1. Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline, Severo Ochoa, 2. 28760 Tres Cantos, Madrid, Spain

2. Medicines for Malaria Venture (MMV), 20, route de Pré-Bois-PO Box 1826, 1215 Geneva 15, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml300008j

Reference20 articles.

1. Drugging the Plasmodium kinome: the benefits of academia–industry synergy

2. Public – private 'partnerships' in health – a global call to action

3. Challenges in antimalarial drug discovery

4. Chemical genetics of Plasmodium falciparum

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