Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures-Reference-Cited by-同舟云学术

Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

Published:2015-02-05 Issue:4 Volume:58 Page:1776-1794
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Monn James A.¹,Prieto Lourdes¹,Taboada Lorena¹,Pedregal Concepcion¹,Hao Junliang¹,Reinhard Matt R.¹,Henry Steven S.¹,Goldsmith Paul J.¹,Beadle Christopher D.¹,Walton Lesley¹,Man Teresa¹,Rudyk Helene¹,Clark Barry¹,Tupper David¹,Baker S. Richard¹,Lamas Carlos¹,Montero Carlos¹,Marcos Alicia¹,Blanco Jaime¹,Bures Mark¹,Clawson David K.¹,Atwell Shane¹,Lu Frances¹,Wang Jing¹,Russell Marijane¹,Heinz Beverly A.¹,Wang Xushan¹,Carter Joan H.¹,Xiang Chuanxi¹,Catlow John T.¹,Swanson Steven¹,Sanger Helen¹,Broad Lisa M.¹,Johnson Michael P.¹,Knopp Kelly L.¹,Simmons Rosa M. A.¹,Johnson Bryan G.¹,Shaw David B.¹,McKinzie David L.¹

Affiliation:

1. Discovery Chemistry Research and Technologies, ‡Quantitative Biology, §Structural Biology, ∥Drug Disposition, and ⊥Neuroscience Research, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501612y

Reference55 articles.

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