Design, Synthesis, Pharmacology, and In Silico Studies of (1<i>S</i>,2<i>S</i>,3<i>S</i>)-2-((<i>S</i>)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu<sub>2</sub> Receptor Agonist-Reference-Cited by-同舟云学术

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Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu₂ Receptor Agonist

Published:2024-01-03 Issue:2 Volume:67 Page:1314-1326
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Na¹,Eshak Floriane²^ORCID,Malhaire Fanny³,Brabet Isabelle³,Prézeau Laurent³,Renard Emma¹,Pin Jean-Philippe³^ORCID,Acher Francine C.²^ORCID,Staudt Markus¹,Bunch Lennart¹^ORCID

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, OE, Denmark

2. Faculty of Basic and Biomedical Sciences, SPPIN CNRS UMR 8003, Université Paris Cité, 75006 Paris, France

3. Institute of Functional Genomics, University of Montpellier, CNRS, 34094 Inserm, Montpellier, France

Funder

Agence Nationale de la Recherche

Danmarks Frie Forskningsfond

China Scholarship Council

Dassault Syst?mes BIOVIA

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01811

Reference54 articles.

1. Glutamate-mediated astrocyte–neuron signalling

2. Glutamate receptors in the mammalian central nervous system

3. The Glutamate Receptors

4. Glutamate, Glutamate Receptors, and Downstream Signaling Pathways

5. Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists;European Journal of Medicinal Chemistry;2024-02

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