Dihydrofuro[3,4-c]pyridinones as Inhibitors of the Cytolytic Effects of the Pore-Forming Glycoprotein Perforin-Reference-Cited by-同舟云学术

Dihydrofuro[3,4-c]pyridinones as Inhibitors of the Cytolytic Effects of the Pore-Forming Glycoprotein Perforin

Published:2008-11-14 Issue:23 Volume:51 Page:7614-7624
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lena Gersande¹,Trapani Joseph A.¹,Sutton Vivien R.¹,Ciccone Annette¹,Browne Kylie A.¹,Smyth Mark J.¹,Denny William A.¹,Spicer Julie A.¹

Affiliation:

1. Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand, and Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Victoria 3002, Australia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801063n

Reference45 articles.

1. Perforin-mediated target-cell death and immune homeostasis

2. Mechanisms of granule-mediated cytotoxicity

3. The Granule Pathway of Programmed Cell Death

4. Lymphocyte-Mediated Cytotoxicity

5. Structure and function of human perforin

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