Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position-Reference-Cited by-同舟云学术

Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position

Published:1998-08-01 Issue:17 Volume:41 Page:3210-3219
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tucker Thomas J.¹,Brady Stephen F.¹,Lumma William C.¹,Lewis S. Dale¹,Gardell Stephen J.¹,Naylor-Olsen Adel M.¹,Yan Youwei¹,Sisko Jack T.¹,Stauffer Kenneth J.¹,Lucas Bobby J.¹,Lynch Joseph J.¹,Cook Jacquelynn J.¹,Stranieri Maria T.¹,Holahan Marie A.¹,Lyle Elizabeth A.¹,Baskin Elizabeth P.¹,Chen I-Wu¹,Dancheck Kimberly B.¹,Krueger Julie A.¹,Cooper Carolyn M.¹,Vacca Joseph P.¹

Affiliation:

1. Departments of Medicinal Chemistry, Biological Chemistry, Pharmacology, Drug Metabolism, and Molecular Design and Diversity, Merck Research Laboratories, West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9801713

Reference8 articles.

1. Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures: Rapid Structure−Activity Studies by Solid-Phase Synthesis

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