Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures: Rapid Structure−Activity Studies by Solid-Phase Synthesis-Reference-Cited by-同舟云学术

Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures: Rapid Structure−Activity Studies by Solid-Phase Synthesis

Published:1998-03-01 Issue:7 Volume:41 Page:1011-1013
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lumma, William C.¹,Witherup Keith M.¹,Tucker Thomas J.¹,Brady Steven F.¹,Sisko John T.¹,Naylor-Olsen Adel M.¹,Lewis S. Dale¹,Lucas Bobby J.¹,Vacca Joseph P.¹

Affiliation:

1. Departments of Medicinal Chemistry, Molecular Design and Diversity, and Biological Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9706933

Reference5 articles.

1. Challenges in the development of orally bioavailable thrombin active site inhibitors

2. Pharmacologic Aspects of the Development of Selective Synthetic Thrombin Inhibitors as Anticoagulants

3. Polymer-bound oxime esters as supports for solid-phase peptide synthesis. The preparation of protected peptide fragments

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