1. Bioscreen Department, Microbial Technologies Department, Analytical Sciences Department, Vicuron Pharmaceuticals, Via R. Lepetit 34, 21040 Gerenzano, Varese, Italy, DBSM, University of Insubria, Via J. H. Dunant 3, 21100, Varese, Italy, and University of Camerino, Via Camerini 2, 62032 Camerino, Italy