Total Synthesis of GE81112A: An Orthoester-Based Approach-Reference-Cited by-同舟云学术

Total Synthesis of GE81112A: An Orthoester-Based Approach

Published:2023-04-06 Issue:9 Volume:88 Page:5597-5608
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Fayad Scherin¹²,Jafari Ardalan²,Schuler Sören M. M.³⁴^ORCID,Kurz Michael¹,Plettenburg Oliver²,Hammann Peter E.⁴⁵,Bauer Armin¹^ORCID,Jürjens Gerrit²³^ORCID,Pöverlein Christoph¹

Affiliation:

1. Sanofi-Aventis Deutschland GmbH, R&D, Integrated Drug Discovery, Industriepark Hoechst, 65926 Frankfurt am Main, Germany

2. Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Institut für Medizinalchemie, 30167 Hannover, Germany

3. Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Bioresources, 35392 Giessen, Germany

4. Evotec International GmbH, 37079 Göttingen, Germany

5. Sanofi-Aventis Deutschland GmbH, R&D, Infectious Diseases, Industriepark Hoechst, 65926 Frankfurt am Main, Germany

Funder

Hessisches Ministerium f?r Wissenschaft und Kunst

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c00094

Reference47 articles.

1. Novel Tetrapeptide Inhibitors of Bacterial Protein Synthesis Produced by a Streptomyces sp.

2. Insights into an Unusual Nonribosomal Peptide Synthetase Biosynthesis

3. Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding

4. Specific, efficient, and selective inhibition of prokaryotic translation initiation by a novel peptide antibiotic

5. Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways