Discovery of 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (Perampanel): A Novel, Noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid (AMPA) Receptor Antagonist
Author:
Affiliation:
1. Medicinal Chemistry, ‡Biopharmacology, and §Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba-shi, Ibaraki 300-2635, Japan
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm301268u
Reference27 articles.
1. Glutamate as a Neurotransmitter in the Brain: Review of Physiology and Pathology
2. Structure and Function of Glutamate Receptor Ion Channels
3. The glutamate story
4. Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
5. Discussion
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