Affiliation:
1. College of Pharmaceutical Science, Institute of Drug Development & Chemical Biology, Zhejiang University
of Technology, Hangzhou 310014, P.R. China
Abstract
Abstract:
According to the 2017 ILAE's official definition, epilepsy is a slow brain dis-ease state characterized by recurrent episodes. Due to information released by ILAE in 2017, it can be divided into four types, including focal epilepsy, generalized epilepsy, combined generalized, and focal epilepsy, and unknown epilepsy. Since 1989, 24 new an-tiepileptic drugs have been approved to treat different types of epilepsy. Besides, there are a variety of antiepileptic medications under clinical monitoring. These novel antiepileptic drugs have plenty of advantages. Over the past 33 years, there have been many antiepilep-tic drugs on the mearket, but no one has been found that can completely cure epilepsy. In this paper, the mentioned drugs were classified according to their targets, and the essential information, and clinical studies of each drug were described. The structure-activity rela-tionship of different chemical structures was summarized. This paper provides help for the follow-up research on epilepsy drugs.
Funder
Science and Technology Program of Zhejiang Province
National Natural Science Foundation of China
Zhejiang Provincial Natural Science Foundation of China
New-shoot Talents Program of Zhejiang Province
Undergraduate Training Program for Innovation and Entrepreneurship of Zhejiang University of Technology
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry