The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7

Author:

Wright Zoë V. F.1,McCarthy Stephen1,Dickman Rachael1,Reyes Francis E.2,Sanchez-Martinez Silvia2,Cryar Adam34,Kilford Ian5,Hall Adrian5,Takle Andrew K.5,Topf Maya4,Gonen Tamir2,Thalassinos Konstantinos34,Tabor Alethea B.1ORCID

Affiliation:

1. Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom

2. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, United States

3. Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, United Kingdom

4. Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, University of London, London WC1E 7HX, United Kingdom

5. European Knowledge Centre, Eisai Limited, Mosquito Way, Hatfield, Hertfordshire AL10 9SN, United Kingdom

Funder

Howard Hughes Medical Institute

Engineering and Physical Sciences Research Council

Basic Energy Sciences

Eisai

Wellcome Trust

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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