A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase
Author:
Affiliation:
1. Structural Biology Laboratory, Department of Chemistry, The University of York, York YO10 5DD, United Kingdom
2. Department of Chemical Immunology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands
Funder
Royal Society
China Scholarship Council
European Commission
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
http://pubs.acs.org/doi/pdf/10.1021/jacs.7b07352
Reference20 articles.
1. Demonstration of the existence of a second, non-lysosomal glucocerebrosidase that is not deficient in Gaucher disease
2. Mutation of β-glucosidase 2 causes glycolipid storage disease and impaired male fertility
3. Identification of the Non-lysosomal Glucosylceramidase as β-Glucosidase 2
4. The Non-lysosomal β-Glucosidase GBA2 Is a Non-integral Membrane-associated Protein at the Endoplasmic Reticulum (ER) and Golgi
5. Gaucher disease and Fabry disease: New markers and insights in pathophysiology for two distinct glycosphingolipidoses
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