Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp3)–H Arylation-Reference-Cited by-同舟云学术

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Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp3)–H Arylation

Published:2017-08-07 Issue:32 Volume:139 Page:11300-11306
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Maetani Micah¹²,Zoller Jochen¹²,Melillo Bruno¹²,Verho Oscar¹²,Kato Nobutaka²,Pu Jun²,Comer Eamon²,Schreiber Stuart L.¹²³^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States

2. Broad Institute, Cambridge, Massachusetts 02142, United States

3. Howard Hughes Medical Institute, Cambridge, Massachussetts 02138, United States

Funder

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

http://pubs.acs.org/doi/pdf/10.1021/jacs.7b06994

Reference55 articles.

1. WHO. World MalariaReport (2016.http://www.who.int/malaria/publications/world_malaria_report_2016/en/, accessed April 1, 2017.

2. Malaria medicines: a glass half full?

3. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

4. Designing the next generation of medicines for malaria control and eradication

5. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

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