Bicyclic Pyrrolidine Inhibitors of <i>Toxoplasma gondii</i> Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure-Reference-Cited by-同舟云学术

Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure

Published:2024-05-14 Issue:6 Volume:10 Page:2212-2221
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Ence Chloe C.¹,Uddin Taher²,Borrel Julien³,Mittal Payal⁴⁵⁶,Xie Han¹,Zoller Jochen³^ORCID,Sharma Amit⁴^ORCID,Comer Eamon³,Schreiber Stuart L.³⁷^ORCID,Melillo Bruno³⁸^ORCID,Sibley L. David²^ORCID,Chatterjee Arnab K.¹^ORCID

Affiliation:

1. Calibr at Scripps Research, La Jolla, California 92037, United States

2. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63130, United States

3. Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, Massachusetts 02142, United States

4. Molecular Medicine-Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India

5. ICMR-NIMR, Sector-8, Dwarka, New Delhi 110077, India

6. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

7. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States

8. Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States

Funder

Science and Engineering Research Board

Division of Microbiology and Infectious Diseases

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.4c00170

Reference19 articles.

1. Innate immunity to Toxoplasma gondii infection

2. In Vitro Characterization of Protein Effector Export in the Bradyzoite Stage of Toxoplasma gondii

3. Toxoplasma gondii infection and its implications within the central nervous system

4. Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice